Monday, January 26, 2009

"Holy Grail" Of Healing Regenerative Powder Helped Re-Grow A Man's Fingertip, And Could Change Medicine Forever

An Ohio man has regrown a finger thanks to a medical miracle that doctors hope will enable patients to regenerate burnt skin and damaged organs, revolutionizing the way the body heals itself.

When Lee Spievack, a hobby-store salesman in Cincinnati, slashed off the tip of his finger with a model-plane propeller, the missing piece vanished along with any reasonable hope of his hand being whole again.

In a cutting-edge medical technique that seems ripped from the pages of science fiction, a powdery substance helped the 69-year-old regrow a fully functional digit with tissue, nerves, skin, nail, and a fingerprint.

Spievack had been helping a customer one evening in August 2005 with an engine on a model airplane behind the shop. He knew the motor was risky because it required somebody to turn the prop backwards to make it run the right way.

"I pointed to it," Spievack recalled the other day, "and said, ‘You need to get rid of this engine, it's too dangerous.' And I put my finger through the prop."

He misjudged the distance to the spinning plastic blade. It sliced off his fingertip, leaving just a bit of the nail bed. The missing piece, three-eighths of an inch long, was never found.

An emergency room doctor wrapped up the rest of his finger and sent him to a hand surgeon, who recommended a skin graft to cover what was left of his finger. What was gone, it appeared, was gone forever.

If Spievack had been a toddler, things might have been different. Up to about age 2, people can consistently regrow fingertips, says Dr. Stephen Badylak, a regeneration expert at the University of Pittsburgh. But that's rare in adults, he said.

Spievack, however, did have a major advantage - a brother, Alan, a former Harvard surgeon who'd founded a company called ACell Inc., that makes an extract of pig bladder for promoting healing and tissue regeneration.

It helps horses regrow ligaments, for example, and the federal government has given clearance to market it for use in people. Similar formulations have been used in many people to do things like treat ulcers and other wounds and help make cartilage.

The summer before Lee Spievack's accident, Dr. Alan Spievack had used it on a neighbor who'd cut his fingertip off on a tablesaw. The man's fingertip grew back over four to six weeks, Alan Spievack said.

Lee Spievack took his brother's advice to forget about a skin graft and try the pig powder.

Soon a shipment of the stuff arrived and Lee Spievack started applying it every two days. Within four weeks his finger had regained its original length, he says, and in four months "it looked like my normal finger."

Spievack said it's a little hard, as if calloused, and there's a slight scar on the end. The nail continues to grow at twice the speed of his other nails.

"All my fingers in this cold weather have cracked except that one," he said.

All in all, he said, "I'm quite impressed."

Behrman/AP

Lee Spievack

Spievack accidentally sliced off the tip of his finger, but regrew it (below) supposedly by using special powder made from pig extract. Spievack/AP

Spievack accidentally sliced off the tip of his finger, but regrew it (below) supposedly by using special powder made from pig extract.

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